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Discovery Data Pipeline

Acellera Therapeutics differential approach to drug discovery is reflected by a uniquely large pipeline of target data with high biological and disease validation.
Pipeline
Target
Target Class
Approach
Tested/Computed
Hit Identification
Hit-to-Lead
Orthosteric

83 / 109

18 hits (low μM IC50)

6 μM, 6 μM, 9 μM, 10 μM, 11 μM

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Ortho & Allosteric

40 / 109

8 hits (low μM IC50)

40 nM, 85 nM

>1000 folds selective against RIPK1

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Orthosteric

19 / 109

12 hits (low μM IC50)

378 nM, 619 nM, 866 nM, 905 nM

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Orthosteric

32 / 109

8 hits (low μM IC50)

30 μM, 47 μM

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Orthosteric

40 / 109

4 hits (low μM IC50)

5 μM, 24 μM

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Orthosteric

40 / 109

2 hits (low μM IC50)

3 μM, 91 μM

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Orthosteric

10 / 106

1 hit via NMR

-

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Allosteric

20 / 106

7 partial hits (high μM IC50)

-

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Allosteric

20 / 106

4 partial hits (high μM IC50)

-

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Allosteric

10 / 106

1 partial hit (high μM IC50)

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Inhibitor

14 / 109

In progress

-

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Agonist

28 / 109

In progress

-

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